Surgery or hair transplants: Surgical hair restoration approaches include various versions of hair transplantation (taking hair from the back and putting it near the front) or scalp reduction (cutting away bald areas and stitching the rest together). Transplant procedures have improved greatly in recent years. They can produce much more attractive and natural-looking results than older methods that sometimes leave a "checkerboard" or hair plug look. Many transplant patients now take Propecia to maintain or keep what they've transplanted. When considering a hair transplant, check the surgeon's credentials and experience carefully. Micrografts are some of the newest techniques whereby surgeons transplant single one to two hair follicles. Hair transplants may be very expensive and time-consuming procedures ranging widely anywhere from $1,000-$20,000, depending on the number of hair grafts transplanted. Typically, 500 or more hairs may be transplanted in a session.
Natural hair that is subjected to constant physical trauma from excessive brushing or combing, tight braids or ponytails, or extreme scratching or massage can cause hair at the temples to become weak and to stop growing to its normal length. Clean shaving, especially for men, can cause white bumps to appear on the area where the hair was shaved short, and at times can become infected with pus and leave permanent scarring, affecting hair growth.
This refers to the habitual pulling or twisting of one's own hair. The scalp and eyelashes are often affected. Unlike alopecia areata patches, which are perfectly smooth, hair patches in trichotillomania show broken-off hairs. Treatment is often entirely behavioral. One has to notice the behavior and then consciously stop. Severe or resistant cases may require stress counseling with a therapist or psychologist or medical treatment with a psychiatrist. Several antidepressant or anti-anxiety medications can help with this condition.
Every part of the body requires thyroid hormone for proper functioning, and that includes the hair follicles. In 2008, the Journal of Clinical Endocrinology and Metabolism presented the first evidence that human hair follicles are direct targets of thyroid hormones. This research demonstrated that the thyroid hormones T4 and T3 modulate multiple hair biology parameters from cycling to pigmentation.
Laser therapy is available in salons and administered by a hair professional who has been trained in the procedure. Treatment is usually two to three times a week. Generally, each session involves a short 8-15 minute exposure of the scalp to the laser device. There is generally no prescribed period of time that the treatment should be administered, although the more frequent and longer the duration, the more effective results have been observed. Noticeable hair growth can be observed after 12 to 26 weeks of treatment. The LLLT is also prescribed as a complementary treatment in post-operative hair surgery.
Once male-pattern baldness starts, it’s not going to stop until every last hair on your head has shrunk or shed, though the rate at which this happens differs from person to person and depends on genetics. And since the grind of hair loss is unending, it’s important to start treatment as soon as your hairline starts bothering you. If you’re looking for a more quantitative metric, Dr. Paul McAndrews, clinical professor of dermatology at the USC School of Medicine and member of the International Society of Hair Restoration Surgery, assures me that “you have to lose half your hair before the human eye can tell.” (Of course, if you don’t care about losing your hair and are fine with going full Prince William and shaving your head, go for it. We’ve got some recommendations for razors and hair trimmers to help you out on that front.)
According to the idea of Ladies Home Journal, frizzy hair can be improved with silicone-based products, which can help fight off frizz while smoothing down the cuticle. Moreover, frizz-fighting products containing certain types of proteins, for example, soy or wheat protein can help with hydration. Lastly, there is something that should not be done in order not to worsen the condition, such as brushing dry hair or over- process hair [4].
Drinking warm water with lemon every morning and before meals has definitely helped increase my stomach acid. I drink it through a straw (I purchased an inexpensive set of stainless steel straws) to prevent damage to the enamel of my teeth. You can also try adding one or two tablespoons of Bragg Organic Unfiltered Apple Cider Vinegar with the ‘Mother’ mixed in water before meals.

Hair practices. Our hair is one of the strongest and most elastic parts of our body. One strand of a healthy hair can be twice as strong as a copper wire of similar thickness. However, not all hair types are equal. Unfortunately, hair care practices and styling can lead to scalp damage and unnecessary pressure on the hair follicles, resulting in hair breakage and loss.
Hair loss vitamins such as Biotin, Niacin (Vitamin B3) and Vitamin C, and minerals for hair loss such as Zinc and Iron, provide essential hair nutrients to nourish healthy and longer hair. Eating enough of these key hair growth vitamins can help prevent hair loss in both men and women. Although some causes of hair loss, such as chemotherapy, illness and medication, may only be moderately affected by a good hair loss diet, in many cases men and women can see great results after only 3-4 months eating more vitamins and minerals for hair growth. 
“The most common cause of hair loss in both men and women is androgenetic alopecia, which is genetic pattern hair loss,” explains Dr. Michael B. Wolfeld, a board-certified plastic surgeon and an assistant clinical professor of plastic surgery at the Icahn School of Medicine at Mount Sinai Hospital in New York. The root cause of this type of hair loss is dihydrotestosterone (DHT), a byproduct of testosterone that shrinks certain hair follicles until they eventually stop producing hair.
Dealing with hair loss is one of the most painful things in the world. It is hard to just sit by and watch as your hair withers away. So – don’t! With all the new technologies and age-old natural remedies, dealing with hair fall has become a lot easier than it used to be. With this handy guide, you too can battle hair loss and come out victorious. Do you know any other ways on how to stop hair loss naturally? Share it with us by leaving a comment below.
Pregnancy may cause many changes in the scalp hair. As the hormones fluctuate during pregnancy, a large number of women feel their hair thickens and becomes fuller. This may be related to change in the number of hairs cycling in the growth phase of hair growth, but the exact reason is unknown. Quite often, there may be a loss of hair (telogen effluvium) after delivery or a few months later which will eventually normalize. 

3. Surgical hair replacement. If you opt for hair transplantation (which runs $5,000 and up), your dermatologist or hair-replacement surgeon will remove single hair follicles from the back of the head, near the nape of the neck, where your hair is fullest. Once those follicles are harvested, they are then dissected and reimplanted into an area of the scalp where hair is thinning. The procedure takes anywhere from three to six hours, and newly implanted hair will usually begin to grow on its own 3 to 12 months after the treatment session. Traditionally, hair transplantation required removal of an entire strip of scalp, Sadick says, but this new follicle-by-follicle technique looks more natural when it heals and allows patients to get heads of hair as dense-looking as before they started losing it.

Hair practices. Our hair is one of the strongest and most elastic parts of our body. One strand of a healthy hair can be twice as strong as a copper wire of similar thickness. However, not all hair types are equal. Unfortunately, hair care practices and styling can lead to scalp damage and unnecessary pressure on the hair follicles, resulting in hair breakage and loss.
While the drug is generally safe for use, some possible side effects are mild irritation of the scalp, dryness and growth of hair on some parts of the body, especially the sides of the face and hands. In some cases, you might observe some increased hair loss around the first few days of use. If the hair fall continues after two weeks upon application of minoxidil, stop the treatment first and see a doctor.
Hair loss can be caused by factors ranging from illness, medication, poor diet, hormones and over-styling. Any one of these causes can interfere with the hair growth cycle, and can prevent hair follicles from growing new hair. We lose on average 100-150 hairs per day, and hair grows at an average of ½ inch per month. But when you notice more extreme hair shedding or slowed hair growth than this, it could be a hair loss symptom. For women, your hair loss symptoms may be thinning hair or gradually more exposed scalp on the top of your head. For men, you may find a growing bald spot on top of your head. About 50% of people have some kind of hair loss by the age of 50. For hair loss symptoms due to aging or hormones, women’s loss tends to be temporary while men’s is most often permanent. But never fear, if men take action early and take supplements for hair growth like Viviscal Man, they can nourish thinning hair to prevent further hair loss symptoms.
Male pattern baldness is caused by a very sensitive reaction to DHT (dihydrotestosterone) – a type of testosterone. This reaction causes the hair follicles (hair roots) to shrink and thereby lose the ability to grow new hair. This process also cuts short the lifespan of hair follicles so you lose hair more quickly. The combination of losing hair more quickly and the slow replacement rate results in baldness.
1. Hair color. Anytime you dye your hair, you’re increasing the diameter of each strand, which can help add volume when your hair is sparse and fine. As a general rule, ask your colorist to make sure highlights are finer at the top of the head, where hair is the thinnest, and more intense at the bottom, where it’s thickest, says Eva Scrivo, a hairstylist and the owner of the Eva Scrivo Salon in New York City. And beware: A color that contrasts with your scalp (blonde tones if your scalp is dark, deep brunettes if your scalp is light) will make any visible scalp more obvious.
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People have between 100,000 and 150,000 hairs on their head. The number of strands normally lost in a day varies but on average is 100.[8] In order to maintain a normal volume, hair must be replaced at the same rate at which it is lost. The first signs of hair thinning that people will often notice are more hairs than usual left in the hairbrush after brushing or in the basin after shampooing. Styling can also reveal areas of thinning, such as a wider parting or a thinning crown.[citation needed]
People have between 100,000 and 150,000 hairs on their head. The number of strands normally lost in a day varies but on average is 100.[8] In order to maintain a normal volume, hair must be replaced at the same rate at which it is lost. The first signs of hair thinning that people will often notice are more hairs than usual left in the hairbrush after brushing or in the basin after shampooing. Styling can also reveal areas of thinning, such as a wider parting or a thinning crown.[citation needed]
The hormonal process of testosterone converting to DHT, which then harms hair follicles, happens in both men and women. Under normal conditions, women have a minute fraction of the level of testosterone that men have, but even a lower level can cause DHT- triggered hair loss in women. And certainly when those levels rise, DHT is even more of a problem. Those levels can rise and still be within what doctors consider “normal” on a blood test, even though they are high enough to cause a problem. The levels may not rise at all and still be a problem if you have the kind of body chemistry that is overly sensitive to even its regular levels of chemicals, including hormones.
Hair concealers and hair fibers. These are one of the newest cosmetic answers to hair loss. As the name suggests, these products are applied on the scalp or hair to camouflage hair loss and give the appearance of fullness to thinning hair. Some of these are applied directly on the scalp, while others (hair fibers) are attached to the hair, much like hair extensions, to add volume.
Instead, you may want to add vitamin D (about $15) to your shopping cart. A vitamin D deficiency can exacerbate hair thinning and make it almost impossible for any over-the-counter product to reverse hair loss, says Dhaval Bhanusali, a dermatologist in New York City, who recommends taking 5,000 international units of D3 a day (and it’s generally beneficial for bone health in women over 40). “There’s also a link between low iron and zinc levels and temporary hair shedding, called [telogen] effluvium,” says Rogers.
Minoxidil (Rogaine) is available over the counter and available in 2%, 4%, and 5% concentrations. It may be something of a nuisance to apply twice daily, but it has been shown to help conserve hair and may even grow some. Minoxidil tends to grow very fine small hairs wherever it is applied. It is important to avoid running the liquid onto the face or neck where it can also grow hair. It is marketed for women at the 2% concentration but may be used in higher strengths as directed by a doctor.
Medications and vitamins: Cancer chemotherapy, which attacks hair follicles in its attempt to kill all fast-growing cells around the body, is a well-known reason for hair loss. Other medications’ side effects include hair shedding as well, such as some that treat high blood pressure and gout (a painful joint condition caused by a buildup of uric acid). Excessive levels of vitamin A also contribute.
The views expressed in this article intend to highlight alternative studies and induce conversation. They are the views of the author and do not necessarily represent the views of hims, and are for informational purposes only, even if and to the extent that this article features the advice of physicians and medical practitioners. This article is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice.
NATURAL INGREDIENTS BACKED BY SCIENCE: We all know how biotin alone can do wonders for your hair, but most aren't aware that it also interacts incredibly well with other ingredients to boost its effectiveness. Our team of experts has formulated a natural, synergistic blend that combines several essential vitamins, minerals, and amino acids that work in conjunction to create a truly superior blend for maximum results.
The follicles on the sides of the scalp are more genetically resistant to DHT, which is why male pattern baldness often results in a “crown” of hair. But its downsides are serious. “With women, finasteride is not an option,” says Dr. Wolfeld. “It’s not FDA-approved for women to take, so we don’t prescribe it.” In fact, due to the drug’s effect on hormone levels, pregnant women are advised to not even touch broken or crushed tablets.
Licorice root. Licorice is an herb that is also used to treat and prevent hair loss and hair damage. It soothes the scalp and helps with dry flakes, dandruff and other forms of scalp irritation. Mix a tablespoon of ground licorice root with a cup of milk and a quarter teaspoon of saffron. Apply the paste on the bald patches and leave it on overnight. Rinse in the morning. You can do this two to three times a week.
Finasteride and minoxidil (for men) and minoxidil (for women) have the best level of evidence for medicines used to treat inherited hair loss.footnote 1, footnote 2 How well finasteride or minoxidil works depends on your age and the location of the hair loss. These medicines don't work for everyone, and you should not expect to regrow a full head of hair.
Pregnancy may cause many changes in the scalp hair. As the hormones fluctuate during pregnancy, a large number of women feel their hair thickens and becomes fuller. This may be related to change in the number of hairs cycling in the growth phase of hair growth, but the exact reason is unknown. Quite often, there may be a loss of hair (telogen effluvium) after delivery or a few months later which will eventually normalize.
But you must start these medical therapies before you lose all your hair. McAndrews likens it to brushing your teeth, in that both are preventative measures. “The sooner you start doing it, the better at slowing down this aging process,” he explains, adding, “Is toothpaste perfect? No, you’re still getting tooth decay with toothpaste, but you’re slowing down tooth decay.”
Traction alopecia - certain hairstyles such as when you pull on your hair tightly can cause scarring of the hair follicles. If pulling is stopped before scarring to the scalp then your hair will grow back normally. Nervous habits such as continual hair pulling or scalp rubbing can also cause scarring and ultimately permanent hair loss. Excessive shampooing and blow-drying can also cause hair loss.
Certain medical conditions call for treatments and surgeries that help to cure the ailment. While these treat your condition, the side effects of the treatments can often damage the hair follicles and cause rapid hair fall. Treatments like chemotherapy to treat cancer, steroids, and medication for typhoid, heart diseases, depression, etc. are known to be responsible for extreme hair fall to the extent of causing baldness. Here’s a list of drugs that list hair loss as a possible side effect:
These medicines slow thinning of the hair and increase coverage of the scalp by growing new hair. They also thicken the shafts of your existing hair so that it grows in thicker. If you stop using the medicine, any hair that has grown in will gradually be lost. Within 6 to 12 months after you stop using the medicine, your scalp will most likely look the same as it did before treatment.

2. Volumizing shampoos and treatments. Typically, these work by depositing ingredients, like wheat protein and keratin, that adhere to the hair shaft to a) thicken it and b) create spaces between hairs so you look like you have more of it. Try Kiehl’s Rice & Wheat Volumizing Shampoo ($18) with hydrolyzed wheat protein; Rogers likes Redken Cerafill Defy Shampoo and Conditioner ($20 each) with ceramides that bulk up hair.
Hair-fiber powders: Colored, powdery fiber sprinkles are commercially available and may work to camouflage balding areas. These colored sprinkles have special properties that help them attach to hair and give a fuller appearance. Toppik is one manufacturer of these products and can be found online. These cosmetic products are available without a prescription, are fairly inexpensive ($20-$40 range), and quite safe with minimal risk. Often these may be used in addition to medical treatments like Rogaine, Propecia, and hair transplants, and they are a great temporary measure to tide one over for special occasions.
There have been reams and reams of paper dedicated to how oiling your hair overnight can make a difference. Well, it is true. Though you may not like the idea of sticky, oily hair, application of oils like almond, coconut, and castor seeds, among others, can help your hair in the long term. Leaving your hair oiled overnight provides enough time for each strand to be coated and for the scalp to get nourished. Dandruff and dead cells are loosened by the movement of your fingers and can be removed easily with shampoo the next day. To give yourself an overnight oil treatment, follow the steps below (keep reading to know more about an oil blend recipe for treating hair loss):

Hair-fiber powders: Colored, powdery fiber sprinkles are commercially available and may work to camouflage balding areas. These colored sprinkles have special properties that help them attach to hair and give a fuller appearance. Toppik is one manufacturer of these products and can be found online. These cosmetic products are available without a prescription, are fairly inexpensive ($20-$40 range), and quite safe with minimal risk. Often these may be used in addition to medical treatments like Rogaine, Propecia, and hair transplants, and they are a great temporary measure to tide one over for special occasions.


When it comes to hair health, what you put in your body is just as important as what you put on your hair. Maintaining a healthy and balanced diet becomes crucial as soon as you notice hair fall. Foods that are rich in Zinc, Iron, Vitamins A, B complex, Vitamin C, Vitamin E, omega-3 fatty acids, and proteins should be consumed. These foods by themselves may go a long way in curbing hair fall as more often than not, hair fall is directly related to a vitamin/mineral deficiency. A healthy diet will also help keep your hair moisturized and nourished, leading to lesser hair fall, fewer split ends, and curbed breakage.
Finasteride is one of the few hair loss treatments to be clinically tested, FDA approved and proven to work for the majority of men. In fact, 83% of the men who take the medicine have successfully stopped male pattern baldness and kept the hair they already have. And 65% of the men who take finasteride have even experienced a noticeable regrowth of lost hair over the course of three months.

Hypotrichosis is a condition of abnormal hair patterns, predominantly loss or reduction. It occurs, most frequently, by the growth of vellus hair in areas of the body that normally produce terminal hair. Typically, the individual's hair growth is normal after birth, but shortly thereafter the hair is shed and replaced with sparse, abnormal hair growth. The new hair is typically fine, short and brittle, and may lack pigmentation. Baldness may be present by the time the subject is 25 years old.[7]


According to practitioners of traditional Chinese medicine, hair health is tied to two things: kidney energy and the blood, which nourish the hair. The solution: acupuncture and Chinese herbs. While there isn't a lot of hard science to back this up, Maureen Conant, a TCM practitioner at Full Bloom Acupuncture in Seattle, says that she's seen women's hair stop falling out and then gradually regenerate after a few months of weekly treatments.
If proper treatments are not carried out, the dry conditions can lead to other serious common hair problems such as frizzy hair, split ends, thinning hair, hair loss, and hair breakage at an early age. Therefore, it is important for you to moisturize and hydrate the hair strands. High- quality conditioner is strongly required for those common hair problems. Some types of essential oils can be perfect choices for you by making your dry hair shiny and soft again. Remember not to comb your hair if it is still wet to avoid breakage and split ends.
While thinning generally worsens after menopause, doctors said hormone treatments typically do not improve hair growth. Minoxidil lotion or foam, which can be purchased over the counter, is the first line of treatment. About half of women who use it have not lost more hair a year later, Cotsarelis said. Spironolactone, a blood-pressure drug, can also help, doctors said. Some may also try finasteride — approved to treat baldness in men — off-label. The evidence that it works in women is weak, Patel said.

Every part of the body requires thyroid hormone for proper functioning, and that includes the hair follicles. In 2008, the Journal of Clinical Endocrinology and Metabolism presented the first evidence that human hair follicles are direct targets of thyroid hormones. This research demonstrated that the thyroid hormones T4 and T3 modulate multiple hair biology parameters from cycling to pigmentation.
Some hair loss can also result from the psychological condition trichotillomania. “People with this condition compulsively pull out their hair when they are stressed or even when they are concentrating, e.g. studying hard,” says Burg. “Sometimes the individual doesn’t know they are pulling their hair out, doing the activity absent-mindedly, and only notice once the bald patches appear.” Over time the hair follicles can become so damaged that they die and leave permanent bald patches. Find out why you shouldn’t pull out gray hairs either.
When it comes to hair health, what you put in your body is just as important as what you put on your hair. Maintaining a healthy and balanced diet becomes crucial as soon as you notice hair fall. Foods that are rich in Zinc, Iron, Vitamins A, B complex, Vitamin C, Vitamin E, omega-3 fatty acids, and proteins should be consumed. These foods by themselves may go a long way in curbing hair fall as more often than not, hair fall is directly related to a vitamin/mineral deficiency. A healthy diet will also help keep your hair moisturized and nourished, leading to lesser hair fall, fewer split ends, and curbed breakage.
Anagen effluvium - is hair loss due to treatment with chemotherapy medicines. These medicines target rapidly dividing cells, so affects the actively growing hair cells. Hair grows back after the treatment is finished. This type of hair loss also occurs with radiation therapy but it is localized to the area of treatment. so if treatment is in the hip area you will lose hair in that area but not the hair on your head.
Female hair loss can have various causes. Thinning hair can be due to changes in your hormones and many women experience some degree of hair loss after pregnancy. In most cases, however, thinning hair occurs as you get older and it is hereditary. This type of hair loss is not dangerous and it does not usually indicate that you suffer from an underlying illness.

Low ferritin (the stored form of iron) is one of the most common causes of hair loss in women. Given low ferritin is also a common problem for hypothyroid people, it is important to have iron testing including ferritin especially if you are experiencing hair loss. It is not enough to be told by your doctor that your iron levels are ‘normal’. Ferritin levels are not always tested. Get a copy of your lab results and be sure ferritin has been specifically tested. Even if ferritin is within the ‘normal’ range that doesn’t make it ‘optimal’.


With sufficient vitamin C, every component related to hair growth gets a boost, which enhances the effects of other essential nutrients. One study from 2006 analyzed patients with androgenic alopecia who were treated with vitamin C and found significant growth stimulation in the hair and scalp, which indicates a link between it and hair follicle growth.  In this study they also found that men with male pattern baldness (alopecia areta) saw significant results after supplementing with Vitamin C.
Thinning hair in women is worth investigating for more than its impact on physical appearance. While many conditions that lead to temporary hair loss will go away without treatment or with simple lifestyle measures, others may be signs of potentially irreversible loss or health conditions. Others yet may respond well to treatments to promote regrowth, so starting sooner rather than later is key.
Just like pregnancy, birth control pills mess with your hormone levels, causing them to fluctuate. In response, you might experience hair loss. “Hormones can interrupt the natural pattern of the hair cycle, causing hairs to shed more quickly than usual or to grow with less vigor,” explains Dominic Burg, PhD, chief scientist for Advangen. Oftentimes the hormone responsible for this is an androgen, such as testosterone, which is why the American Hair Loss Association recommends low-androgen birth control pills for those who are at an increased risk for hair loss.
Drinking warm water with lemon every morning and before meals has definitely helped increase my stomach acid. I drink it through a straw (I purchased an inexpensive set of stainless steel straws) to prevent damage to the enamel of my teeth. You can also try adding one or two tablespoons of Bragg Organic Unfiltered Apple Cider Vinegar with the ‘Mother’ mixed in water before meals.
Finasteride, also known as the brand name Propecia, is a pill that is FDA approved to prevent hair loss. But don’t confuse this for being a miracle cure for baldness. There’s no such thing as a magical cure that stops male pattern baldness. However, finasteride can be an effective way to prevent your hair from thinning because it prohibits the conversion of testosterone into DHT (dihydrotestosterone). DHT is a powerful hormone that causes hair follicles to miniaturize and eventually stop growing hair. You get this benefit as long as you take it properly and consistently as prescribed by your doctor.
NATURAL INGREDIENTS BACKED BY SCIENCE: We all know how biotin alone can do wonders for your hair, but most aren't aware that it also interacts incredibly well with other ingredients to boost its effectiveness. Our team of experts has formulated a natural, synergistic blend that combines several essential vitamins, minerals, and amino acids that work in conjunction to create a truly superior blend for maximum results.
Acupuncture is a form of Chinese medicine that has been practiced for thousands of years. Its applications are many, and some researchers believe that it may help with hair loss from alopecia areata. How? The needles inserted into the scalp may help stimulate hair follicles and promote regrowth. More research needs to be done in this area, but consider asking your doctor for a referral to a licensed acupuncturist if this treatment sounds appealing to you. (Learn more about acupuncture for hair loss.)
As a senior writer for Live Science, Laura Geggel covers general science, including the environment and amazing animals. She has written for The New York Times, Scholastic, Popular Science and Spectrum, a site covering autism research. Laura grew up in Seattle and studied English literature and psychology at Washington University in St. Louis before completing her graduate degree in science writing at NYU. When not writing, you'll find Laura playing Ultimate Frisbee. Follow Laura on Google+.  

However, the high incidence of androgenic alopecia is caused by the male hormones. Testosterone in the scalp is converted into dihydrotestosterone (DHT) that causes the follicles to shrink in size, therefore inhibiting the growth of hair, which eventually leads to baldness. However, hair follicles on the sides and back of the head do not have as much DHT compared to the top, hence why hair loss is concentrated on the crown of the head. Interestingly, DHT is known to help in the growth of the beard and hair on the chest, a reason why most bald men have hairy chests and grow their beards much faster.

A key aspect of hair loss with age is the aging of the hair follicle.[43] Ordinarily, hair follicle renewal is maintained by the stem cells associated with each follicle. Aging of the hair follicle appears to be primed by a sustained cellular response to the DNA damage that accumulates in renewing stem cells during aging.[44] This damage response involves the proteolysis of type XVII collagen by neutrophil elastase in response to the DNA damage in the hair follicle stem cells. Proteolysis of collagen leads to elimination of the damaged cells and then to terminal hair follicle miniaturization.
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